BUFFERING TECHNIQUE FOR OBTAINING INCREASED PHYSIOLOGICAL RESPONSE FROM ALKALOIDAL EYE-DROPS

Buffering technique for obtaining increased physiological response from alkaloidal eye-drops.

IT is widely accepted that the physiological activity of alkaloidal eye preparations results from the penetration through the cornea of the free base portion rather than of the ionic form of the alkaloid (Cogan and Kinsey, 1942; Cogan and Hirsch, 1944; Swan and White, 1942). Therefore, the smaller the pKb value of the alkaloid, the fewer free base particles will be available for drug action at ...

A method for the obtaining of increased viscosity eye drops containing amikacin.

A method for the obtaining of increased viscosity (3.6-52.5 cP) eye drops, containing amikacin-aminoglycoside antibiotic and as increasing viscosity agents: polivinyl alkohol, hydroxyethylcellulose or sodium hyaluronate was elaborated. Physicochemical and biological properties of these eye drops were determined.

Specifications for eye-drops.

Correspondence MEDIALJOUH How much easier it would be if platelet stickiness were expressed as the percentage of sticky platelets rather than as the percentage of non-sticky platelets, and how much more logical. That is: Platelet stickiness (%)= (Original Count minus Second Count) x 100 Original Count With this simple transformation a high value would indicate a high degree of sticki-ness, and ...

Anticholinergic visual hallucinosis from atropine eye drops.

A 37-year-old man with type I diabetes mellitus and chronic renal failure presented to the emergency department complaining of hallucinations. He was 5 days postoperative for left pars plana vitrectomy and intra-ocular lens implantation and had been taking ophthalmic atropine, tobramycin and prednisolone. He had presented 5 months earlier, on the same ophthalmic medications, with postoperative ...

Eye-drops in Tonometry.